| Dimethyltryptamin
(DMT) has a long history of use and is found in
a variety of plants and seeds. It can also be produced
synthetically. It is ineffective when taken orally,
unless combined with another drug that inhibits
its metabolism. Generally it is sniffed, smoked,
or injected. The effective hallucinogenic dose in
humans is about 50 to 100 mg and lasts for about
45 to 60 minutes. Because the effects last only
about an hour; the experience has been referred
to as a "businessman’s trip."
A number of other hallucinogens have very similar
structures and properties to those of DMT. Diethyltryptamine
(DET), for example, is an analogue of DMT and
produces the same pharmacological effects but
is somewhat less potent than DMT. Alpha-ethyltryptamine
(AET) is another tryptamine hallucinogen added
to the list of Schedule I hallucinogens in 1994.
Bufotenine (5-hydroxy-N-N-dimethyltryptamine)
is a Schedule I substance found in certain mushrooms,
seeds, and skin glands of Bufo toads. In general,
most bufotenine preparations from natural sources
are extremely toxic. N,N-Diisopropyl-5-methoxytryptamine
(referred to as Foxy-Methoxy) is an orally active
tryptamine recently encountered in the United
States.
Source: DEA
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