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| Glutethimide
& Methaqualone |
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Glutethimide
(Doriden®) was introduced in 1954 and methaqualone
("Quaalude" Sopor®) in 1965 as safe
barbiturate substitutes. Experience demonstrated,
however; that their addiction liability and the
severity of withdrawal symptoms were similar to
those of barbiturates. By 1972, "luding out,"
taking methaqualone with wine, was a popular college
pastime. Excessive use leads to tolerance, dependence,
and withdrawal symptoms similar to those of barbiturates.
In the United States, the marketing of methaqualone
pharmaceutical products stopped in 1984, and methaqualone
was transferred to Schedule I of the CSA. In 1991,
glutethimide was transferred into Schedule II in
response to an upsurge in the prevalence of diversion,
abuse, and overdose deaths. Today, there is little
medical use of glutethimide in the United States.
Source: DEA
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